Influence of Cobalt, Sheep Erythropoietin and Several Hormones on Erythropoiesis in Bone Marrows of Isolated Perfused Hind Limbs of Dogs.
نویسندگان
چکیده
By JAMES W. FIsm R, B. L. ROH, CHARLES COUCH AND W. 0. NIGHTINGALE E RYTHROPOIESIS is known to be stimulated by several hormonal substances. ACTH,12 adrenocortical steroids,34 thyrotrophic and thyroid hormones,1’5 growth hormone3 and testosterone are hormones that have been shown to stimulate erythropoiesis in either intact or hypophysectomized rats. Cobalt has been known for several decades to stimulate erythropoiesis7 and its effects have been found to be significantly reduced when the kidneys were removed.8 Although cobalt’s primary effect is through the release of kidney
منابع مشابه
Erythropoiesis. Regulatory Mechanisms and Developmental Aspects
This volume contains the proceedings of a conference on erythropoiesis held at Tel Aviv University from July 27-29, 1970. Twenty-seven papers are listed under six headings: "Fetal and Neonatal Erythropoiesis," "Assay of Erythropoietin," "Androgens and Erythropoiesis," "Mechanism of Action of Erythropoietin," "Regulation of Erythropoiesis," and "Production of Erythropoietin: Renal and Extrarenal...
متن کاملThe influence of hypoxemia and cobalt on erythropoietin production in the isolated perfused dog kidney.
By JAMES W. FIsIIEII AND J. W. LANGSTON SEVERAL WORKERS have demonstrated that hypoxia 4 and cobalt5 stimulate the release or production of erythropoietin in the isolated perfused kidney. Other investigators0’7 have found elevated plasma levels of erythropoietin iii animals following renal artery constriction. Higher erythropoictin levels were found in renal venous blood than renal arterial blo...
متن کاملThe Influence of Cobalt and Sheep Erythropoietin on Radioactive Iron Incorporation in RBC of Starved
By NEIL P. SANZARI AND JAMES W. FISHER A REVIEW of the recent literature concerning the site of erythropoietin production unmistakably reveals the existence of conflicting views as to the role of the kidney in erythropoiesis.1M Experimental observations from several laboratories indicate that the kidney is a primary source of at least one erythropoietic hormone.14 However, there is good evidenc...
متن کاملThe influence of cobalt and sheep erythropoietin on radioactive iron incorporation in RBC of starved intact and nephrectomized rats.
By NEIL P. SANZARI AND JAMES W. FISHER A REVIEW of the recent literature concerning the site of erythropoietin production unmistakably reveals the existence of conflicting views as to the role of the kidney in erythropoiesis.1M Experimental observations from several laboratories indicate that the kidney is a primary source of at least one erythropoietic hormone.14 However, there is good evidenc...
متن کاملEvidence for a physiologic role of erythropoietin in fetal erythropoiesis.
Administration of antibody prepared in spleen, and bone marrow, effects ascribrabbits against human urinary Ep to fetal able to a neutralization of endogenous Ep. sheep during the last third of the gestaIn addition, there was a significant dotion period resulted in a suppression of crease in the numbers of nucleated cryerythropoiesis in the fetus. This was throid cells in the bone marrows of th...
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ورودعنوان ژورنال:
- Blood
دوره 23 شماره
صفحات -
تاریخ انتشار 1964